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pentobarbital will reduce the level or result of eplerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.pentobarbital will lower the extent or impact of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with sturdy CYP3A4 inducers just isn't advisa